Serveur d'exploration COVID et hydrochloroquine

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Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.

Identifieur interne : 000B85 ( Main/Exploration ); précédent : 000B84; suivant : 000B86

Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.

Auteurs : Sebastian E. Sattui [États-Unis] ; Jean W. Liew [États-Unis] ; Elizabeth R. Graef [États-Unis] ; Ariella Coler-Reilly [États-Unis] ; Francis Berenbaum [France] ; Alí Duarte-García [États-Unis] ; Carly Harrison [États-Unis] ; Maximilian F. Konig [États-Unis] ; Peter Korsten [Allemagne] ; Michael S. Putman [États-Unis] ; Philip C. Robinson [Australie] ; Emily Sirotich [Canada] ; Manuel F. Ugarte-Gil [Pérou] ; Kate Webb [Afrique du Sud, Royaume-Uni] ; Kristen J. Young [États-Unis] ; Alfred H J. Kim [États-Unis] ; Jeffrey A. Sparks [États-Unis]

Source :

RBID : pubmed:32620062

Descripteurs français

English descriptors

Abstract

INTRODUCTION

Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public.

AREAS COVERED

We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions toward hydroxychloroquine may shift from early enthusiasm (based on

EXPERT OPINION

Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation.


DOI: 10.1080/1744666X.2020.1792778
PubMed: 32620062
PubMed Central: PMC7594186


Affiliations:


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Le document en format XML

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<name sortKey="Graef, Elizabeth R" sort="Graef, Elizabeth R" uniqKey="Graef E" first="Elizabeth R" last="Graef">Elizabeth R. Graef</name>
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<nlm:affiliation>Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, USA.</nlm:affiliation>
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<name sortKey="Coler Reilly, Ariella" sort="Coler Reilly, Ariella" uniqKey="Coler Reilly A" first="Ariella" last="Coler-Reilly">Ariella Coler-Reilly</name>
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<nlm:affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine , St. Louis, MO, USA.</nlm:affiliation>
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<name sortKey="Berenbaum, Francis" sort="Berenbaum, Francis" uniqKey="Berenbaum F" first="Francis" last="Berenbaum">Francis Berenbaum</name>
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<nlm:affiliation>Department of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP , Paris, France.</nlm:affiliation>
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<wicri:regionArea>Department of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP , Paris</wicri:regionArea>
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<region type="region">Île-de-France</region>
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<name sortKey="Duarte Garcia, Ali" sort="Duarte Garcia, Ali" uniqKey="Duarte Garcia A" first="Alí" last="Duarte-García">Alí Duarte-García</name>
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<nlm:affiliation>Division of Rheumatology, Mayo Clinic , Rochester, MN, USA.</nlm:affiliation>
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<name sortKey="Webb, Kate" sort="Webb, Kate" uniqKey="Webb K" first="Kate" last="Webb">Kate Webb</name>
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<nlm:affiliation>Department of Paediatric Rheumatology, University of Cape Town , Cape Town, South Africa.</nlm:affiliation>
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<wicri:regionArea>Department of Paediatric Rheumatology, University of Cape Town , Cape Town</wicri:regionArea>
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<nlm:affiliation>Francis Crick Institute , London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
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<settlement type="city">Londres</settlement>
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<name sortKey="Young, Kristen J" sort="Young, Kristen J" uniqKey="Young K" first="Kristen J" last="Young">Kristen J. Young</name>
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<nlm:affiliation>Division of Rheumatic Diseases, UT Southwestern Medical Center , Dallas, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatic Diseases, UT Southwestern Medical Center , Dallas, TX</wicri:regionArea>
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<region type="state">Texas</region>
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<name sortKey="Kim, Alfred H J" sort="Kim, Alfred H J" uniqKey="Kim A" first="Alfred H J" last="Kim">Alfred H J. Kim</name>
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<nlm:affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine , Saint Louis, MO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, Department of Medicine, Washington University School of Medicine , Saint Louis, MO</wicri:regionArea>
<placeName>
<region type="state">Missouri (État)</region>
</placeName>
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<name sortKey="Sparks, Jeffrey A" sort="Sparks, Jeffrey A" uniqKey="Sparks J" first="Jeffrey A" last="Sparks">Jeffrey A. Sparks</name>
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<title level="j">Expert review of clinical immunology</title>
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<term>Antiviral Agents (therapeutic use)</term>
<term>Betacoronavirus (drug effects)</term>
<term>COVID-19 (MeSH)</term>
<term>Communication (MeSH)</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Humans (MeSH)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Public Opinion (MeSH)</term>
<term>SARS-CoV-2 (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Antiviraux (usage thérapeutique)</term>
<term>Betacoronavirus (effets des médicaments et des substances chimiques)</term>
<term>Communication (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Opinion publique (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Résultat thérapeutique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Antiviral Agents</term>
<term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Betacoronavirus</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
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<term>Betacoronavirus</term>
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<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
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<term>Antiviraux</term>
<term>Hydroxychloroquine</term>
</keywords>
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<term>COVID-19</term>
<term>Communication</term>
<term>Humans</term>
<term>Pandemics</term>
<term>Public Opinion</term>
<term>SARS-CoV-2</term>
<term>Treatment Outcome</term>
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<term>Communication</term>
<term>Humains</term>
<term>Opinion publique</term>
<term>Pandémies</term>
<term>Résultat thérapeutique</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>INTRODUCTION</b>
</p>
<p>Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>AREAS COVERED</b>
</p>
<p>We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions toward hydroxychloroquine may shift from early enthusiasm (based on </p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>EXPERT OPINION</b>
</p>
<p>Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation.</p>
</div>
</front>
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<Month>09</Month>
<Day>25</Day>
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<Year>2021</Year>
<Month>05</Month>
<Day>07</Day>
</DateRevised>
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<ISSN IssnType="Electronic">1744-8409</ISSN>
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<Volume>16</Volume>
<Issue>7</Issue>
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<Year>2020</Year>
<Month>07</Month>
</PubDate>
</JournalIssue>
<Title>Expert review of clinical immunology</Title>
<ISOAbbreviation>Expert Rev Clin Immunol</ISOAbbreviation>
</Journal>
<ArticleTitle>Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19.</ArticleTitle>
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<MedlinePgn>659-666</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/1744666X.2020.1792778</ELocationID>
<Abstract>
<AbstractText Label="INTRODUCTION">Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public.</AbstractText>
<AbstractText Label="AREAS COVERED">We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. We aimed to explore how opinions toward hydroxychloroquine may shift from early enthusiasm (based on
<i>in vitro</i>
and preliminary clinical data) to the hope for a miracle cure (through communication and promotion of questionable results) and, finally, to a rise of skepticism as more in-depth analyses are emerging.</AbstractText>
<AbstractText Label="EXPERT OPINION">Mindful and rigorous acquisition of data, as well as its interpretation, are essential to an effective pandemic response. The rapid and premature promotion of results has had major implications for global crisis management, even creating distrust among the public. It is crucial for the medical and scientific community to incorporate the lessons learned from this situation.</AbstractText>
</Abstract>
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<LastName>Sattui</LastName>
<ForeName>Sebastian E</ForeName>
<Initials>SE</Initials>
<Identifier Source="ORCID">0000-0002-3945-6828</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Department of Medicine, Hospital for Special Surgery , New York, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Liew</LastName>
<ForeName>Jean W</ForeName>
<Initials>JW</Initials>
<Identifier Source="ORCID">0000-0002-8104-2450</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Department of Medicine, University of Washington , Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Graef</LastName>
<ForeName>Elizabeth R</ForeName>
<Initials>ER</Initials>
<Identifier Source="ORCID">0000-0001-5973-3477</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Coler-Reilly</LastName>
<ForeName>Ariella</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0001-8549-6559</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine , St. Louis, MO, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Berenbaum</LastName>
<ForeName>Francis</ForeName>
<Initials>F</Initials>
<Identifier Source="ORCID">0000-0001-8252-7815</Identifier>
<AffiliationInfo>
<Affiliation>Department of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP , Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Duarte-García</LastName>
<ForeName>Alí</ForeName>
<Initials>A</Initials>
<Identifier Source="ORCID">0000-0003-1749-5719</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Mayo Clinic , Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Harrison</LastName>
<ForeName>Carly</ForeName>
<Initials>C</Initials>
<Identifier Source="ORCID">0000-0001-6291-587X</Identifier>
<AffiliationInfo>
<Affiliation>LupusChat , New York, NY, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Konig</LastName>
<ForeName>Maximilian F</ForeName>
<Initials>MF</Initials>
<Identifier Source="ORCID">0000-0001-5045-5255</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine , Baltimore, MD, USA.</Affiliation>
</AffiliationInfo>
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<LastName>Korsten</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<Identifier Source="ORCID">0000-0001-6065-5680</Identifier>
<AffiliationInfo>
<Affiliation>Department of Nephrology and Rheumatology, University Medical Center Göttingen , Göttingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Putman</LastName>
<ForeName>Michael S</ForeName>
<Initials>MS</Initials>
<Identifier Source="ORCID">0000-0001-9699-4000</Identifier>
<AffiliationInfo>
<Affiliation>Department of Medicine, Northwestern University , Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Robinson</LastName>
<ForeName>Philip C</ForeName>
<Initials>PC</Initials>
<Identifier Source="ORCID">0000-0002-3156-3418</Identifier>
<AffiliationInfo>
<Affiliation>University of Queensland Faculty of Medicine , Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sirotich</LastName>
<ForeName>Emily</ForeName>
<Initials>E</Initials>
<Identifier Source="ORCID">0000-0002-7087-8543</Identifier>
<AffiliationInfo>
<Affiliation>Department of Health Research Methods, Evidence, and Impact, McMaster University , Hamilton, ON, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Canadian Arthritis Patient Alliance , Toronto, ON, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ugarte-Gil</LastName>
<ForeName>Manuel F</ForeName>
<Initials>MF</Initials>
<Identifier Source="ORCID">0000-0003-1728-1999</Identifier>
<AffiliationInfo>
<Affiliation>School of Medicine, Universidad Científica Del Sur and Hospital Nacional Guillermo Almenara Irigoyen , EsSalud, Lima, Peru.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Webb</LastName>
<ForeName>Kate</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">0000-0003-1087-5946</Identifier>
<AffiliationInfo>
<Affiliation>Department of Paediatric Rheumatology, University of Cape Town , Cape Town, South Africa.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Francis Crick Institute , London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Young</LastName>
<ForeName>Kristen J</ForeName>
<Initials>KJ</Initials>
<Identifier Source="ORCID">0000-0001-8570-2228</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatic Diseases, UT Southwestern Medical Center , Dallas, TX, USA.</Affiliation>
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</Author>
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<LastName>Kim</LastName>
<ForeName>Alfred H J</ForeName>
<Initials>AHJ</Initials>
<Identifier Source="ORCID">0000-0003-4074-0516</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Department of Medicine, Washington University School of Medicine , Saint Louis, MO, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Sparks</LastName>
<ForeName>Jeffrey A</ForeName>
<Initials>JA</Initials>
<Identifier Source="ORCID">0000-0002-5556-4618</Identifier>
<AffiliationInfo>
<Affiliation>Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School , Boston, MA, USA.</Affiliation>
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<Agency>NIAMS NIH HHS</Agency>
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<Acronym>AR</Acronym>
<Agency>NIAMS NIH HHS</Agency>
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<Country>United States</Country>
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<Agency>NIAMS NIH HHS</Agency>
<Country>United States</Country>
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<li>Angleterre</li>
<li>Basse-Saxe</li>
<li>Grand Londres</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Missouri (État)</li>
<li>Texas</li>
<li>Washington (État)</li>
<li>État de New York</li>
<li>Île-de-France</li>
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